RESEARCH

The foundation of our research is the development of chemical tools and methods with applications that span from medicinal chemistry to radiological sciences. The lab takes an interdisciplinary approach, combining elements of organic synthesis, catalysis, and biology to address problems of clinical importance. Ultimately, we leverage our expertise in biomedical imaging and chemical biology to develop clinically relevant diagnostic techniques and small-molecule therapeutics.

We establish new metal-catalyzed processes that can rapidly produce key structural motifs embodied in bioactive molecules.

We develop molecular therapeutics that have a clinical significance in the treatment of cancer. These studies include the design, synthesis, modeling, and evaluation of kinase activators and inhibitors.

We design imaging probes for hyperpolarized 13C MRI. These HP 13C agents assess key metabolic pathways in order to facilitate cancer diagnosis, treatment monitoring, and improve our understanding of metabolic diseases.