RESEARCH

Our research focuses on developing chemical tools and methods that advance medicine and biomedical imaging. We integrate organic synthesis, catalysis, and chemical biology to address clinically important problems, with an emphasis on developing molecular imaging technologies and small-molecule therapeutics. By bridging chemistry and the biomedical sciences, we translate fundamental chemical discoveries into new diagnostic and therapeutic approaches.

We establish new metal-catalyzed processes that can rapidly produce key structural motifs embodied in bioactive molecules.

We develop molecular therapeutics that have a clinical significance in the treatment of cancer. These studies include the design, synthesis, modeling, and evaluation of kinase activators and inhibitors.

We design imaging probes for hyperpolarized 13C MRI. These HP 13C agents assess key metabolic pathways in order to facilitate cancer diagnosis, treatment monitoring, and improve our understanding of metabolic diseases.